MDR was identified in 30 (33.3%) isolates. Multidrug resistance (MDR) was observed in 24 isolates (44.4%) with a multiple antibiotic resistance index ranging from 0.44 to 0.77. Eight (14.8%) isolates showed resistance to imipenem however, none of the isolates showed resistance to colistin. The isolates exhibited significantly (p ≤ 0.05) increased resistance to piperacillin (77.8%), ciproflox-acin (59.3%), gentamicin (50%), and ceftazidime (38.9%). The identification of ST2012 was significantly (p ≤ 0.05) higher than that of ST296, ST308, ST111, and ST241.
Multi-locus sequence typing identified ten different sequence types for the P. Isolates were identified biochemically to the genus level by the automated Vitek 2 system and genetically by the amplification of the gyrB gene and the sequencing of the 16S rRNA gene. Among the 180 uterine swabs and 90 drinking water samples analysed, 54 (20%) P. aeruginosa isolated from the uterus of cow, camel, and mare with clinical endometritis and their drinking water. This study aimed to investigate the genetic diversity, antimicrobial resistance, biofilm formation, and virulence and antibiotic resistance genes of P. Pseudomonas aeruginosa is a ubiquitous opportunistic bacterium that causes diseases in animals and humans.
#JESSICA PRIM ACTIVATOR#
– 1,90 ± 0,34 mg/ml and inhibitor of tissue plasminogen activator type I – 45,8 ± 0,9 IU/ml at the lowest level of tissue plasminogen activator – 0,38 ± 0,08 IU/ml (according to the norms 1,1–1,3 IU/ml) and protein C deficiency In obstetric and gynecological pathology, the hypercoagulable state is aggravated to consumption coagulopathy, which is reflected in high plasma levels of soluble fibrin – 0,064 ± 0,005 g/l, fibrin / fibrinogen cleavage products – 7,5 ± 0,4 μg/ml, functionally inactive forms of prothrombi. The main hemostasiological criteria are the levels: in phase I – fibrinogen 4,9–6,1 g/l, soluble fibrin about 0,04 g/l, activated partial thromboplastin time 38,1–39,7 s, functionally inactive forms prothrombin 0,88 ± 0,2 mg/ml in the first month of pregnancy in phase II – fibrinogen 5,1–7,0 g/l, soluble fibrin about 0,01 g/l, functionally inactive forms of prothrombin 0,17 ± 0,05 mg/ml and protein C 72,0 ± 1,4 % after childbirth. The activation of hemostasis components is correlated with a high level of natural anticoagulant protein C and increased fibrinolysis activity through tissue plasminogen activator, which is controlled by a high level of its type I inhibitor. It is established that the physiological course of the gestational process occurs with the intensification of coagulation processes in the hemostasis system with thrombophilia, which has a two–phase nature – from the first month of pregnancy to the seventh and in the period of 2–3 days to calving with a peak of hypercoagulation by 2–5 that day after birth.
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